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0  发表于: 2010-11-05  

History lessons

In 1953, a German   company invited a new kind of medicine-“Thalidomide”. This became a real tragic disaster of fetus in the consequent decade.  Some pregnant women used thalidomide to treat sickness of Women who took the drug in early pregnancy gave birth to children with   birth defects such as missing or shortened limbs.[1]  October 1961, in a meet of German obstetricians and gynaecologists, three GP report that thousands of birth defects. Those babies have not arms and legs, and hands and foods directly linked with their bodies.[1] They looks like   seals, therefore they were called Phocomelia. Shortly after, the birth defects were observed in England, Canadian, Australia, Japan and Brail et.. . Mothers who had taken the drug when arms and legs were beginning to form had babies with a widely varying but recognizable pattern of limb deformities. The affected babies almost always had both sides affected and often had both the arms and the legs malformed. The congenital anomalies included shortened limbs, missing limbs, missing hands, missing feet missing fingers missing ears and missing eyes. The state of California has identified thalidomide as a developmental hazard, which means there is proof that it may harm unborn children. The U.S. Food and Drug Administration (FDA) refused approving thalidomide, there fore only few cases were found in America at that time. These case control study suggest that Thalidomide and Phocomelia are associated. From April1962 to mach1963, only 10 months 5500 Phocomelia were bored in German, 8000 cases were report in England, and 300 cases were reported in Japan. [1] Some cohort studies are strong evidence to suggest that Thalidomide and Phocomelia are associated each other. Thalidomide was banned worldwide. From then on, there were not too much cases of phocomelia been reported. This was other an evidence of the association. However, as time went by, scientists found that thalidomide is effective in treating symptoms of diseases such as leprosy and possibly AIDS. FDA approved thalidomide in 1998 in order to treat leprosy.[2] The FDA has established several restrictions. Doctors prescribing and pharmacists dispensing thalidomide are required, and patients must also be educated about the drug's effects, in order to avoid tragic birth defects. Studies are also being conducted to determine the effectiveness of thalidomide in treating symptoms associated with AIDS, Behcet disease, lupus, Sjogren syndrome, rheumatoid arthritis, inflammatory bowel disease, macular degeneration, and some cancers. 2002, Nanjing baby and mother hospital, the Department of gynaecologists reported a barber bored a Phocomelia after touching imported chemical.   [size=14pt]                                                   (End)Reference:
1: Barsch M, Otte A. The legal standards for the radioactive or non radioactive drugs research and approval in the European Community and in Germany after the thalidomide catastrophe. Hell J Nucl Med. 2010 Jan-Apr;13(1):45-51. PubMed PMID: 20411171.



2: Mujagić H, Chabner BA, Mujagić Z. Mechanisms of action and potential therapeutic uses of thalidomide. Croat Med J. 2002 Jun;43(3):274-85. Review.

PubMed PMID: 12035132.

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1  发表于: 2012-05-28  
The historic story of Thalidomide(沙利度胺) tells every medical practitioner  :
1. Medicines can be very harmful to patients , in the long run . We should be very careful n considerate to use them .
2. The poisonous medicines can be used as another medications if we know how to avoid the side effects .

sometimes , a practitioner needs both scientific and artistic eyes .
http://www.hbclinic.net      为海外中医发展而努力!
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